Since faking his own death, Arthur Bishop has been living quietly in Rio de Janeiro under the name Santos. He is approached by a courier, Renee Tran, who knows his true identity and explains that her employer wishes Bishop to kill three targets and stage their deaths as accidents.

Bishop escapes, eluding her and her mercenaries and fleeing to Thailand. He takes shelter at the resort island beach house of his friend, Mei, and learns that Tran is working for Riah Crain.